TKA-731

• Description :

  TKA-731 is an NK1 receptor antagonist. TKA-731 can reverse mechanical hyperalgesia. TKA-731 can be used for research on neuropathic pain[1].

• CAS Number :

  [210776-01-5]

• UNSPSC :

  12352005

• Target :

  Neurokinin Receptor

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Field of Research :

  Neurological Disease

• Smiles :

  O=C(N([C@H](C(N(C)CC1=CC=CC=C1)=O)CC2=CC=C(C=CC=C3)C3=C2)C)[C@H](CCC4)N4C5=NC(C6=CC=CC=C6N5)=O

• Molecular Formula :

  C35H35N5O3

• Molecular Weight :

  573.68

• References & Citations :

  [1]Sindrup SH, et al. The NK1-receptor antagonist TKA731 in painful diabetic neuropathy: a randomised, controlled trial. Eur J Pain. 2006 Aug;10 (6) :567-71.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2

• Isoform :

  NK1R