nor-NOHA (monoacetate)

nor-NOHA (monoacetate)

• CAS Number: 2250019-93-1
• UNSPSC Description: nor-NOHA monoacetate is a selective and reversible arginase inhibitor. nor-NOHA monoacetate induces apoptosis in ARG2-expressing cells under hypoxia. nor-NOHA monoacetate has anti-leukemic activity. nor-NOHA monoacetate can used in study of endothelial dysfunction, immunosuppression and metabolism[1].
• Target Antigen: Arginase
• Type: Reference compound
• Related Pathways: Immunology/Inflammation;Metabolic Enzyme/Protease
• Applications: Metabolism-protein/nucleotide metabolism
• Field of Research: Metabolic Disease
• Assay Protocol: https://www.medchemexpress.com/nor-noha-monoacetate.html
• Purity: 99.96
• Solubility: DMSO : 100 mg/mL (ultrasonic)|H2O : 50 mg/mL (ultrasonic)
• Smiles: N[C@H](C(O)=O)CCNC(NO)=N.O=C(C)O
• Molecular Weight: 236.23
• References & Citations: [1]Ng KP, et al. The arginase inhibitor Nω-hydroxy-nor-arginine (nor-NOHA) induces apoptosis in leukemic cells specifically under hypoxic conditions but CRISPR/Cas9 excludes arginase 2 (ARG2) as the functional target. PLoS One. 2018 Oct 11;13(10):e0205254.|[2]Jung C, et al. Arginase inhibition mediates cardioprotection during ischaemia-reperfusion. Cardiovasc Res. 2010 Jan 1;85(1):147-54.Front Cell Dev Biol. 2021 Dec 23;9:741911.|Clin Immunol. 2024 Sep 3:110355.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
• Clinical Information: Phase 1