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Nor-NOHA (acetate)

CAT: 0804-HY-112885A-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-112885A-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Nor-NOHA acetate is a selective and reversible arginase inhibitor. nor-NOHA acetate induces apoptosis in ARG2-expressing cells under hypoxia. nor-NOHA acetate has anti-leukemic activity. nor-NOHA acetate improves liver ischemia-reperfusion injury. nor-NOHA acetate can used in study of tuberculosis, endothelial dysfunction, immunosuppression and metabolism[1][2][3][4].
CAS Number
1140844-63-8
Product Name Alternative
Nω-Hydroxy-nor-L-arginine (acetate)
UNSPSC
12352211
Target
Apoptosis; Arginase
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer; Inflammation/Immunology; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/nor-NOHA_acetate.html
Concentration
10mM
Purity
99.5
Solubility
H2O : 100 mg/mL (ultrasonic)
Smiles
O=C(O)[C@@H](N)CCNC(NO)=N.CC(O)=O.CC(O)=O
Molecular Formula
C9H20N4O7
Molecular Weight
296.28
References & Citations
[1]Ng KP, et al. The arginase inhibitor Nω-hydroxy-nor-arginine (nor-NOHA) induces apoptosis in leukemic cells specifically under hypoxic conditions but CRISPR/Cas9 excludes arginase 2 (ARG2) as the functional target. PLoS One. 2018 Oct 11;13 (10) :e0205254.|[2]Jung C, et al. Arginase inhibition mediates cardioprotection during ischaemia-reperfusion. Cardiovasc Res. 2010 Jan 1;85 (1) :147-54.|[3]Reid KM, et al. Liver I/R injury is improved by the arginase inhibitor, N (omega) -hydroxy-nor-L-arginine (nor-NOHA) . Am J Physiol Gastrointest Liver Physiol. 2007 Feb;292 (2) :G512-7. |[4]Chauhan , et al. Therapeutic Modulation of Arginase with nor-NOHA Alters Immune Responses in Experimental Mouse Models of Pulmonary Tuberculosis including in the Setting of Human Immunodeficiency Virus (HIV) Co-Infection. Trop Med Infect Dis. 2024 Jun 6;9 (6) :129.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 1

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