Brigimadlin intermediate-1

• Description:

  Brigimadlin intermediate-1 is an intermediate of the E3 ubiquitin protein ligase MDM-2 inhibitor Brigimadlin (HY-152859) and can be used to synthesize Antibody-Drug Conjugates (ADCs) .

• UNSPSC:

  12352203

• Hazard Statement:

  H315-H319-H320

• Target:

  Drug Intermediate

• Type:

  ADC Related

• Related Pathways:

  Others

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/brigimadlin-intermediate-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(OC)C1=CC=C(N)C([N+]([O-])=O)=C1C

• Molecular Formula:

  C9H10N2O4

• Molecular Weight:

  210.19

• Precautions:

  P264-P280-P302+P352-P305+P351+P338-P362

• References & Citations:

  [1]Gollner Andreas, et al. Preparation of spiroindolepyrrolidinone derivatives for use as MDM2-p53 inhibitors: World Intellectual Property Organization, WO2017060431. 2017-04-13.|[2]WHO Drug Information-World Health Organization (WHO) .|[3]Hao X, et al. BI-907828, a novel potent MDM2 inhibitor, inhibits glioblastoma brain tumor stem cells in vitro and prolongs survival in orthotopic xenograft mouse models. Neuro Oncol. 2023 May 4;25 (5) :913-926.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  ADC Related

• Clinical Information:

  No Development Reported

• CAS Number:

  [1149388-04-4]