Brigimadlin intermediate-1

• Description :

  Brigimadlin intermediate-1 is an intermediate of the E3 ubiquitin protein ligase MDM-2 inhibitor Brigimadlin (HY-152859) and can be used to synthesize Antibody-Drug Conjugates (ADCs) .

• UNSPSC :

  12352203

• Hazard Statement :

  H315-H319-H320

• Target :

  Drug Intermediate

• Type :

  ADC Related

• Related Pathways :

  Others

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/brigimadlin-intermediate-1.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(OC)C1=CC=C(N)C([N+]([O-])=O)=C1C

• Molecular Formula :

  C9H10N2O4

• Molecular Weight :

  210.19

• Precautions :

  P264-P280-P302+P352-P305+P351+P338-P362

• References & Citations :

  [1]Gollner Andreas, et al. Preparation of spiroindolepyrrolidinone derivatives for use as MDM2-p53 inhibitors: World Intellectual Property Organization, WO2017060431. 2017-04-13.|[2]WHO Drug Information-World Health Organization (WHO) .|[3]Hao X, et al. BI-907828, a novel potent MDM2 inhibitor, inhibits glioblastoma brain tumor stem cells in vitro and prolongs survival in orthotopic xenograft mouse models. Neuro Oncol. 2023 May 4;25 (5) :913-926.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  ADC Related

• Clinical Information :

  No Development Reported

• CAS Number :

  [1149388-04-4]