Leukotriene B5

• CAS Number:

  80445-66-5

• UNSPSC Description:

  Leukotriene B5 (LTB5) is a leukotriene with diverse biological activities. It is a metabolite of eicosapentaenoic acid formed through the 5-lipoxygenase (5-LO) pathway. LTB5 increases contraction of bullfrog lung strips ex vivo in a concentration-dependent manner. In vivo, LTB5 (100 nM) reduces tumor volume in mice injected with Tm1 murine melanoma cells. LTB5 also elicits chemokinesis and lysosomal enzyme release from polymorphonuclear leukocytes (PMNLs) 20- to 30-fold less, and induces platelet aggregation 8-fold less, potently than LTB4.

• Target Antigen:

  Others

• Type:

  Reference compound

• Related Pathways:

  Others

• Applications:

  Cancer-programmed cell death

• Field of Research:

  cancer

• Assay Protocol:

  https://www.medchemexpress.com/leukotriene-b5.html

• Smiles:

  CC/C=C\C/C=C\C[C@@H](O)/C=C/C=C/C=C\[C@@H](O)CCCC(O)=O

• Molecular Weight:

  334.45

• References & Citations:

  [1]Terano, et al. Biosynthesis and biological activity of leukotriene B5. Prostaglandins 27(2), 217-232 (1984).

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported