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Tiotropium (Bromide)

CAT: 0804-HY-17360-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-17360-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Tiotropium Bromide (BA679 BR) is a muscarinic acetylcholine receptor (mAChR) antagonist that blocks the binding of the acetylcholine ligand and subsequent opening of the ligand-gated ion channel.
CAS Number
136310-93-5
Product Name Alternative
BA679 BR
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
MAChR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Tiotropium-Bromide.html
Purity
99.91
Solubility
DMSO : 250 mg/mL (ultrasonic) |H2O : 25 mg/mL (ultrasonic)
Smiles
O=C(C(C1=CC=CS1)(O)C2=CC=CS2)O[C@H]3C[C@H]([N+]4(C)C)[C@@H]5O[C@@H]5[C@H]4C3.[Br-]
Molecular Formula
C19H22BrNO4S2
Molecular Weight
472.42
Precautions
H302, H315, H319, H335
References & Citations
[1]Barnes PJ. Tiotropium bromide. Expert Opin Investig Drugs. 2001 Apr;10 (4) :733-40.|[2]ZuWallack AR, ZuWallack RL. Tiotropium bromide, a new, once-daily inhaled anticholinergic bronchodilator for chronic-obstructive pulmonary disease. Expert Opin Pharmacother. 2004 Aug;5 (8) :1827-35.|[3]Lipson DA. Tiotropium bromide. Int J Chron Obstruct Pulmon Dis. 2006;1 (2) :107-14.|[4]Mamary AJ, Criner GJ. Tiotropium bromide for chronic obstructive pulmonary disease. Expert Rev Respir Med. 2009 Jun;3 (3) :211-20.|[5]Szmidt M. [The influence of treatment with formoterol, formoterol with tiotropium, formoterol with inhaled glucocorticosteroid and tiotropium on lung functions, tolerance of exercise and simple, morning everyday activities in patients with chronic obstructive pulmonary disease (COPD) ]. Pneumonol Alergol Pol. 2012;80 (3) :255-62.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched

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