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Tiotropium-d3 (bromide)

CAT: 0804-HY-17360SSize: 500 µgDry Ice: NoHazardous: No
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CAT#:0804-HY-17360SSize:500 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Tiotropium-d3 (bromide) is the deuterium labeled Tiotropium (Bromide) . Tiotropium Bromide (BA679 BR) is a muscarinic acetylcholine receptor (mAChR) antagonist that blocks the binding of the acetylcholine ligand and subsequent opening of the ligand-gated ion channel.
CAS Number
1127226-56-5
Product Name Alternative
BA679 BR-d3
UNSPSC
12352005
Target
Isotope-Labeled Compounds; mAChR
Type
Isotope-Labeled Compounds
Related Pathways
GPCR/G Protein; Neuronal Signaling; Others
Field of Research
Neurological Disease
Solubility
10 mM in DMSO
Smiles
[2H]C([2H])([2H])[N@+]1(C)[C@H](C2)[C@](O3)([H])[C@]3([H])[C@@H]1C[C@@H]2OC(C(C4=CC=CS4)(C5=CC=CS5)O)=O.[Br-]
Molecular Formula
C19H19D3BrNO4S2
Molecular Weight
475.43
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Barnes PJ. Tiotropium bromide. Expert Opin Investig Drugs. 2001 Apr;10 (4) :733-40.; ZuWallack AR, ZuWallack RL. Tiotropium bromide, a new, once-daily inhaled anticholinergic bronchodilator for chronic-obstructive pulmonary disease. Expert Opin Pharmacother. 2004 Aug;5 (8) :1827-35.; Lipson DA. Tiotropium bromide. Int J Chron Obstruct Pulmon Dis. 2006;1 (2) :107-14.; Mamary AJ, Criner GJ. Tiotropium bromide for chronic obstructive pulmonary disease. Expert Rev Respir Med. 2009 Jun;3 (3) :211-20.; Szmidt M. [The influence of treatment with formoterol, formoterol with tiotropium, formoterol with inhaled glucocorticosteroid and tiotropium on lung functions, tolerance of exercise and simple, morning everyday activities in patients with chronic obstructive pulmonary disease (COPD) ]. Pneumonol Alergol Pol. 2012;80 (3) :255-62.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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