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7-Hydroxyneolamellarin A

CAT: 0804-HY-N10330Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-N10330Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
7-Hydroxyneolamellarin A is a natural product that could be derived from sponge Dendrilla nigra. 7-Hydroxyneolamellarin A is a potent hypoxia-inducible factor-1α (HIF-1α) inhibitor. 7-Hydroxyneolamellarin A attenuates the accumulation of hypoxia-inducible factor-1α (HIF-1α) protein and inhibits vascular epidermal growth factor (VEGF) transcriptional activity. 7-Hydroxyneolamellarin A can be used in research of cancer[1].
CAS Number
959662-26-1
UNSPSC
12352005
Target
HIF/HIF Prolyl-Hydroxylase; VEGFR
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/7-hydroxyneolamellarin-a.html
Solubility
10 mM in DMSO
Smiles
OC1=CC=C(C(O)C(N2C=C(C3=CC=C(O)C=C3)C(C4=CC=C(O)C=C4)=C2)=O)C=C1
Molecular Formula
C24H19NO5
Molecular Weight
401.41
References & Citations
[1]Li G, et, al. Total synthesis and biological evaluation of 7-hydroxyneolamellarin A as hypoxia-inducible factor-1α inhibitor for cancer therapy. Bioorg Med Chem Lett. 2021 Oct 15;50:128338.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

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