5-BDBD

• Description :

  5-BDBD, a potent and selective P2X4 receptor antagonist, inhibits rP2X4R-mediated currents, with an IC50 of 0.75 μM. 5-BDBD completely blocks the basal and acute hyperalgesia induced by nitroglycerin (NTG) [1][2].

• UNSPSC :

  12352005

• Hazard Statement :

  H302

• Target :

  P2X Receptor

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/5-bdbd.html

• Concentration :

  10mM

• Purity :

  99.94

• Solubility :

  DMSO : 62.5 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  O=C1CN=C(C2=CC=CC(Br)=C2)C(OC3=CC=CC=C34)=C4N1

• Molecular Formula :

  C17H11BrN2O2

• Molecular Weight :

  355.19

• Precautions :

  H302

• References & Citations :

  [1]Coddou C, et al. Characterization of the antagonist actions of 5-BDBD at the rat P2X4 receptor. Neurosci Lett. 2019;690:219-224.|[2]Long T, et al. Microglia P2X4 receptor contributes to central sensitization following recurrent nitroglycerin stimulation. J Neuroinflammation. 2018;15 (1) :245. Published 2018 Aug 30.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  P2X4 Receptor

• CAS Number :

  [768404-03-1]