MS31 (trihydrochloride)

• UNSPSC Description:

  MS31 trihydrochloride is a potent, highly affinity and selective fragment-like methyllysine reader protein spindlin 1 (SPIN1) inhibitor. MS31 trihydrochloride potently inhibits the interactions between SPIN1 and H3K4me3 (IC50=77 nM, AlphaLISA; 243 nM, FP). MS31 trihydrochloride selectively binds Tudor domain II of SPIN1 (Kd=91 nM). MS31 trihydrochloride potently inhibits binding of trimethyllysine-containing peptides to SPIN1, and is not toxic to nontumorigenic cells[1].

• Target Antigen:

  Epigenetic Reader Domain

• Type:

  Reference compound

• Related Pathways:

  Epigenetics

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ms31-trihydrochloride.html

• Purity:

  98.0

• Solubility:

  DMSO : 62.5 mg/mL (ultrasonic)

• Smiles:

  NCC1=CC(CN)=C(OC)C(OCCCN2CC(C=CC=C3)=C3C2)=C1.[H]Cl.[H]Cl.[H]Cl

• Molecular Weight:

  450.83

• References & Citations:

  [1]Xiong Y, et al. Discovery of a Potent and Selective Fragment-like Inhibitor of Methyllysine Reader Protein Spindlin 1(SPIN1). J Med Chem. 2019 Jul 24.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Clinical Information:

  No Development Reported

• CAS Number:

  2748239-18-9