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SID 7969543

CAT: 0804-HY-107404-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-107404-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SID 7969543 is a selective SF-1 (steroidogenic factor 1, NR5A1) inhibitor with an IC50 of 760 nM. SID 7969543 inhibits SF-1-triggered luciferase expression with IC50 of 30 nM. SF-1 is a transcription factor belonging to the nuclear receptor superfamily[1][2].
CAS Number
868224-64-0
UNSPSC
12352005
Target
Orphan Nuclear Receptor; Orphan Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/sid-7969543.html
Purity
99.42
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CCOC(C(C)OC1=C2C(C(N(CC(NC3=CC=C(OCCO4)C4=C3)=O)C=C2)=O)=CC=C1)=O
Molecular Formula
C24H24N2O7
Molecular Weight
452.46
References & Citations
[1]Madoux F, et al. Potent, selective and cell penetrant inhibitors of SF-1 by functional ultra-high-throughput screening. Mol Pharmacol. 2008;73 (6) :1776-1784.|[2]Roth J, et al. Synthesis of small molecule inhibitors of the orphan nuclear receptor steroidogenic factor-1 (NR5A1) based on isoquinolinone scaffolds. Bioorg Med Chem Lett. 2008;18 (8) :2628-2632.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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