T-26c

T-26c

• CAS Number: 869296-13-9
• UNSPSC Description: T-26c is highly potent and selective matrix metalloproteinase-13 (MMP-13) inhibitor with an IC50 of 6.75 pM and more than 2600-fold selectivity over the other related metalloenzymes[1].
• Target Antigen: MMP
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/T-26c.html
• Purity: 99.52
• Solubility: DMSO : 15.62 mg/mL (ultrasonic)
• Smiles: COC1=CC=CC(CNC(C2=NC(SC=C3COCC4=CC=C(C(O)=O)C=C4)=C3C(N2)=O)=O)=C1
• Molecular Weight: 479.51
• References & Citations: [1]Nara H, et al. Thieno[2,3-d]pyrimidine-2-carboxamides bearing a carboxybenzene group at 5-position: highly potent, selective, and orally available MMP-13 inhibitors interacting with the S1″ binding site. Bioorg Med Chem. 2014 Oct 1;22(19):5487-505.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported