Undecane-d24

CAT: 0804-HY-N8593S-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-N8593S-01Size:5 mg
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Description
Undecane-d24 is the deuterium labeled Undecane (HY-N8593) .Undecane is a potent cAMP agonist with anti-allergic and anti-inflammatory activities. Undecane inhibits degranulation and the secretion of histamine and TNF-α. Undecane reverses the increased levels of p38 phosphorylation, NF-κB transcriptional activity and target cytokine/chemokine genes, including thymus and activation-regulated chemokine (TARC), macrophage-derived chemokine (MDC) and interleukin-8 (IL-8) . Undecane can be used for the study of skin inflammatory disorders, such as atopic dermatitis[1].
CAS Number
[164858-54-2]
UNSPSC
12352211
Target
Histamine Receptor; Interleukin Related; Isotope-Labeled Compounds; NF-κB; p38 MAPK; PKA; TNF Receptor
Type
Isotope-Labeled Compounds
Related Pathways
Apoptosis; GPCR/G Protein; Immunology/Inflammation; MAPK/ERK Pathway; Neuronal Signaling; NF-κB; Others; Stem Cell/Wnt; TGF-beta/Smad
Applications
COVID-19-immunoregulation
Field of Research
Endocrinology; Inflammation/Immunology
Solubility
10 mM in DMSO
Smiles
[2H]C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H]
Molecular Formula
C11D24
Molecular Weight
180.46
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Choi D, Kang W, Park T. Anti-Allergic and Anti-Inflammatory Effects of Undecane on Mast Cells and Keratinocytes. Molecules. 2020;25 (7) :1554. Published 2020 Mar 28.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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