Undecane-d24

• Description :

  Undecane-d24 is the deuterium labeled Undecane (HY-N8593) .Undecane is a potent cAMP agonist with anti-allergic and anti-inflammatory activities. Undecane inhibits degranulation and the secretion of histamine and TNF-α. Undecane reverses the increased levels of p38 phosphorylation, NF-κB transcriptional activity and target cytokine/chemokine genes, including thymus and activation-regulated chemokine (TARC), macrophage-derived chemokine (MDC) and interleukin-8 (IL-8) . Undecane can be used for the study of skin inflammatory disorders, such as atopic dermatitis[1].

• UNSPSC :

  12352211

• Target :

  Histamine Receptor; Interleukin Related; Isotope-Labeled Compounds; NF-κB; p38 MAPK; PKA; TNF Receptor

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  Apoptosis; GPCR/G Protein; Immunology/Inflammation; MAPK/ERK Pathway; Neuronal Signaling; NF-κB; Others; Stem Cell/Wnt; TGF-beta/Smad

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Endocrinology; Inflammation/Immunology

• Solubility :

  10 mM in DMSO

• Smiles :

  [2H]C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H]

• Molecular Formula :

  C11D24

• Molecular Weight :

  180.46

• References & Citations :

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Choi D, Kang W, Park T. Anti-Allergic and Anti-Inflammatory Effects of Undecane on Mast Cells and Keratinocytes. Molecules. 2020;25 (7) :1554. Published 2020 Mar 28.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported

• CAS Number :

  [164858-54-2]