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Undecane

CAT: 0804-HY-N8593-01Size: 10 gDry Ice: NoHazardous: No
CAT#:0804-HY-N8593-01Size:10 g
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Description
Undecane is a potent cAMP agonist with anti-allergic and anti-inflammatory activities. Undecane inhibits degranulation and the secretion of histamine and TNF-α. Undecane reverses the increased levels of p38 phosphorylation, NF-κB transcriptional activity and target cytokine/chemokine genes, including thymus and activation-regulated chemokine (TARC), macrophage-derived chemokine (MDC) and interleukin-8 (IL-8) . Undecane can be used for the study of skin inflammatory disorders, such as atopic dermatitis[1].
CAS Number
[1120-21-4]
UNSPSC
12352211
Hazard Statement
H226, H304
Target
Histamine Receptor; Interleukin Related; NF-κB; p38 MAPK; PKA; TNF Receptor
Type
Natural Products
Related Pathways
Apoptosis; GPCR/G Protein; Immunology/Inflammation; MAPK/ERK Pathway; Neuronal Signaling; NF-κB; Stem Cell/Wnt; TGF-beta/Smad
Applications
COVID-19-immunoregulation
Field of Research
Endocrinology; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/undecane.html
Purity
99.66
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CCCCCCCCCCC
Molecular Formula
C11H24
Molecular Weight
156.31
Precautions
H226, H304
References & Citations
[1]Choi D, Kang W, Park T. Anti-Allergic and Anti-Inflammatory Effects of Undecane on Mast Cells and Keratinocytes. Molecules. 2020;25 (7) :1554. Published 2020 Mar 28.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
IL-10; IL-8; NF-κB; p38 MAPK; PKA

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