Undecane

• Description:

  Undecane is a potent cAMP agonist with anti-allergic and anti-inflammatory activities. Undecane inhibits degranulation and the secretion of histamine and TNF-α. Undecane reverses the increased levels of p38 phosphorylation, NF-κB transcriptional activity and target cytokine/chemokine genes, including thymus and activation-regulated chemokine (TARC), macrophage-derived chemokine (MDC) and interleukin-8 (IL-8) . Undecane can be used for the study of skin inflammatory disorders, such as atopic dermatitis[1].

• UNSPSC:

  12352211

• Hazard Statement:

  H226, H304

• Target:

  Histamine Receptor; Interleukin Related; NF-κB; p38 MAPK; PKA; TNF Receptor

• Type:

  Natural Products

• Related Pathways:

  Apoptosis; GPCR/G Protein; Immunology/Inflammation; MAPK/ERK Pathway; Neuronal Signaling; NF-κB; Stem Cell/Wnt; TGF-beta/Smad

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Endocrinology; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/undecane.html

• Purity:

  99.66

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  CCCCCCCCCCC

• Molecular Formula:

  C11H24

• Molecular Weight:

  156.31

• Precautions:

  H226, H304

• References & Citations:

  [1]Choi D, Kang W, Park T. Anti-Allergic and Anti-Inflammatory Effects of Undecane on Mast Cells and Keratinocytes. Molecules. 2020;25 (7) :1554. Published 2020 Mar 28.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• Isoform:

  IL-10; IL-8; NF-κB; p38 MAPK; PKA

• CAS Number:

  [1120-21-4]