RR-11a analog

RR-11a analog

• CAS Number: 685543-66-2
• UNSPSC Description: RR-11a analog is a potent and irreversible inhibitor of Schistosoma mansoni legumain, with an IC50 of 31 nM. RR-11a analog is an aza-Asn derivative and aza-peptide Michael acceptor[1][2].
• Target Antigen: Legumain; Parasite
• Type: Reference compound
• Related Pathways: Anti-infection;Neuronal Signaling
• Applications: COVID-19-immunoregulation
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/RR-11a_analog.html
• Purity: 99.12
• Solubility: DMSO : 125 mg/mL (ultrasonic)|H2O : 2.5 mg/mL (ultrasonic;warming;heat to 60°C)
• Smiles: O=C(N[C@@H](C)C(N[C@@H](C)C(NN(CC(N)=O)C(/C=C/C(OCC)=O)=O)=O)=O)OCC1=CC=CC=C1
• Molecular Weight: 491.49
• References & Citations: [1]Götz MG, et al. Aza-peptidyl Michael acceptors. A new class of potent and selective inhibitors of asparaginyl endopeptidases (legumains) from evolutionarily diverse pathogens. J Med Chem. 2008 May 8;51(9):2816-32.|[2]Ekici OD, et al. Aza-peptide Michael acceptors: a new class of inhibitors specific for caspases and other clan CD cysteine proteases. J Med Chem. 2004 Apr 8;47(8):1889-92.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported