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NKCC2 Antibody (APC)

CAT: 0013-GTR18029425Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18029425Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Rabbit polyclonal to NKCC2 (APC) . NKCC2, a kidney-specific member of the cation chloride co-transporter family SLC12, facilitates transport of sodium, potassium, and chloride ions from the lumen of the renal thick ascending limb into the cell. Transport of sodium dilutes the luminal fluid, decreasing its osmolality creating an osmotic driving force for water reabsorption in the connecting tubule and cortical collecting duct under the influence of the hormone vasopressin. NKCC2 is found on the apical surface of the thick ascending limb of the loop of Henle and is blocked by loop diuretics such as furosemide..
Product Name Alternative
SLC12A1, sodium potassium chloride cotransporter 2, sodium-potassium-chloride cotransporter isoform 2, BSC1, MBSC1, Na-K-2Cl cotransporter, NKCC2A variant A, RBSC
UniProt
Q5PQV1
Reactivity
Human, Mouse, Rat
Immunogen
Produced against a synthetic peptide mapping to a segment (amino acids 33-55) of the N-terminal tail of rat NKCC2 (antibody designation L224) .
Target
NKCC2
Clonality
Polyclonal
Conjugation
APC
Field of Research
Neuroscience
Purification
Protein A Purified
Concentration
1 mg/ml
Dilution
WB (1:1000) ; IHC (1:25)
Molecular Weight
160kDa
Storage Conditions
Conjugated antibodies should be stored according to the product label
Notes
For research use only.
Applications Notes
1 μg/ml was sufficient for detection of NKCC2 in 10 μg of rat kidney tissue lysate by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.
Tested Applications
IHC, WB
NCBI Accession Number
NP_001257546.1
Host or Source
Rabbit
Preservative
95.46mM Phosphate, 2.48mM MES and 2mM EDTA
Entrez
25065

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