Fumagillin

Fumagillin

• CAS Number: 23110-15-8
• UNSPSC Description: Fumagillin(NSC9168) is an antimicrobial compound first isolated in 1949 from the fungus Aspergillus fumigatu. Fumagillin can inhibits HIV‐1 infection through the inhibition of HIV-1 viral protein R (Vpr) activity.
• Target Antigen: Antibiotic; HIV; Parasite
• Type: Natural Products
• Related Pathways: Anti-infection
• Applications: COVID-19-anti-virus
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/fumagillin.html
• Purity: 99.0
• Solubility: DMSO : 142.86 mg/mL (ultrasonic)|H2O : < 0.1 mg/mL
• Smiles: C[C@]1([C@@H](C/C=C(C)/C)O1)[C@]([C@@H]2OC)([H])[C@]3(CC[C@H]2OC(/C=C/C=C/C=C/C=C/C(O)=O)=O)CO3
• Molecular Weight: 458.54
• References & Citations: [1]Lefkove, B., B. Govindarajan, and J.L. Arbiser, Fumagillin: an anti-infective as a parent molecule for novel angiogenesis inhibitors. Expert Rev Anti Infect Ther, 2007. 5(4): p. 573-9.|[2]Watanabe N, et al. Fumagillin suppresses HIV-1 infection of macrophages through the inhibition of Vpr activity. FEBS Lett. 2006 May 15;580(11):2598-602.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, stored under nitrogen)
• Clinical Information: Launched