Phenylephrine

• UNSPSC Description:

  (R)-(-)-Phenylephrine is a selective α1-adrenoceptor agonist primarily used as a decongestant.

• Target Antigen:

  Adrenergic Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein;Neuronal Signaling

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Cardiovascular Disease; Endocrinology; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/_R_-_-_-Phenylephrine.html

• Purity:

  99.94

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)|H2O : 5 mg/mL (ultrasonic)

• Smiles:

  O[C@H](C1=CC(O)=CC=C1)CNC

• Molecular Weight:

  167.208

• References & Citations:

  [1]Ford AP, et al. Pharmacological pleiotropism of the human recombinant alpha1A-adrenoceptor: implications foralpha1-adrenoceptor classification. Br J Pharmacol. 1997 Jul;121(6):1127-35.|[2]Minneman KP, et al. Selectivity of agonists for cloned alpha 1-adrenergic receptor subtypes. Mol Pharmacol. 1994 Nov;46(5):929-36.|[3]Wang J, et al. Phenylephrine promotes cardiac fibroblast proliferation through calcineurin-NFAT pathway. Front Biosci (Landmark Ed). 2016 Jan 1;21:502-13.|[4]Lazou A, et al. Activation of mitogen-activated protein kinases (p38-MAPKs, SAPKs/JNKs and ERKs) by the G-protein-coupled receptor agonist phenylephrine in the perfused rat heart. Biochem J. 1998 Jun 1;332 ( Pt 2):459-65.|[5]Li NJ, et al. Effect of phenylephrine on alveolar fluid clearance in ventilator-induced lung injury. Chin Med Sci J. 2013 Mar;28(1):1-6.Biochem Biophys Res Commun. 2024 Oct 17:735:150844.|Biochim Biophys Acta Mol Basis Dis. 2023 Aug 27;166859.|Biochim Biophys Acta Mol Basis Dis. 2024 Aug 30:167488.|BMC Pulm Med. 2021 Jun 5;21(1):189.|Front Med. 2024 May 14.|J Cardiovasc Pharmacol. 2022 Sep 1;80(3):430-441.|J Endod. 2023 Sep 26:S0099-2399(23)00608-8.|J Ethnopharmacol. 2024 Aug 22:118707.|Mol Med Rep. July 6, 2021.|Nat Commun. 2024 Jul 16;15(1):5985.|Sci Rep. 2023 Oct 2;13(1):16550.|Elife. 2024 May 29.|Free Radic Biol Med. 2024 Jan 6:S0891-5849(24)00007-8.|Front Cardiovasc Med. 2021 Jun 16;8:679240.|J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Aug 15;1092:220-227.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  Launched

• CAS Number:

  59-42-7