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Phenylephrine (hydrochloride)

CAT: 0804-HY-B0471-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0471-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(R) - (-) -Phenylephrine hydrochloride is a selective α1-adrenoceptor agonist with pKis of 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively.
CAS Number
61-76-7
Product Name Alternative
(R) - (-) -Phenylephrine (hydrochloride) ; L-Phenylephrine (hydrochloride)
UNSPSC
12352005
Hazard Statement
H302, H317, H401
Target
Adrenergic Receptor; Endogenous Metabolite
Type
Reference compound
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease; Endocrinology; Cancer
Assay Protocol
https://www.medchemexpress.com/_r_-_-_-phenylephrine-hydrochloride.html
Concentration
10mM
Purity
99.99
Solubility
DMSO : 125 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)
Smiles
OC1=CC([C@@H](O)CNC)=CC=C1.Cl
Molecular Formula
C9H14ClNO2
Molecular Weight
203.67
Precautions
H302, H317, H401
References & Citations
[1]Ford AP, et al. Pharmacological pleiotropism of the human recombinant alpha1A-adrenoceptor: implications foralpha1-adrenoceptor classification. Br J Pharmacol. 1997 Jul;121 (6) :1127-35.|[2]Minneman KP, et al. Selectivity of agonists for cloned alpha 1-adrenergic receptor subtypes. Mol Pharmacol. 1994 Nov;46 (5) :929-36.|[3]Wang J, et al. Phenylephrine promotes cardiac fibroblast proliferation through calcineurin-NFAT pathway. Front Biosci (Landmark Ed) . 2016 Jan 1;21:502-13.|[4]Lazou A, et al. Activation of mitogen-activated protein kinases (p38-MAPKs, SAPKs/JNKs and ERKs) by the G-protein-coupled receptor agonist phenylephrine in the perfused rat heart. Biochem J. 1998 Jun 1;332 (Pt 2) :459-65.|[5]Li NJ, et al. Effect of phenylephrine on alveolar fluid clearance in ventilator-induced lung injury. Chin Med Sci J. 2013 Mar;28 (1) :1-6.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
α adrenergic receptor
Citation 01
BioRxiv. 2025 Jul 30.|bioRxiv. 2025 Jun 27:2025.06.24.660441.|Elife. 2024 May 29.|Free Radic Biol Med. 2024 Feb 20:212:477-492.|Front Cardiovasc Med. 2021 Jun 16:8:679240.|J Cell Mol Med. 2025 Mar;29 (5) :e70488.|J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Aug 15:1092:220-227.|Mater Des. 2025 Aug.|Biochem Biophys Res Commun. 2024 Nov 26:735:150844.|Biochem Pharmacol. 2025 Aug 8;242 (Pt 1) :117218.|Biochem Pharmacol. 2025 Oct:240:117107.|Biochim Biophys Acta Mol Basis Dis. 2024 Aug 30:167488.|Biochim Biophys Acta Mol Basis Dis. 2024 Jan;1870 (1) :166859.|BMC Cardiovasc Disord. 2025 Jan 6;25 (1) :7.|BMC Pulm Med. 2021 Jun 5;21 (1) :189.|Cell Signal. 2026 Feb:138:112275.|Clin Exp Pharmacol Physiol. 2025 Nov;52 (11) :e70081.|Eur J Pharmacol. 2025 Feb 1:177346.|FASEB J. 2025 May 31;39 (10) :e70670.|Free Radic Biol Med. 2025 Jun 7:237:300-311.|Front Med. 2024 Jun;18 (3) :484-498.|Int Endod J. 2025 Jul 14.|J Adv Res. 2025 Oct 29:S2090-1232 (25) 00848-3.|J Cardiovasc Pharmacol. 2022 Sep 1;80 (3) :430-441.|J Endod. 2023 Dec;49 (12) :1641-1651.e6.|J Ethnopharmacol. 2024 Aug 22:118707.|Mol Med Rep. 2021 Sep;24 (3) :636.|Nat Commun. 2024 Jul 16;15 (1) :5985.|Phytother Res. 2025 May 26.|Sci Rep. 2023 Oct 2;13 (1) :16550.|Sci Rep. 2025 Apr 11;15 (1) :12511.|Trends Biotechnol. 2025 Apr;43 (4) :918-945.

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