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Pholedrine (hydrochloride)

CAT: 0804-HY-121609A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-121609A-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Pholedrine hydrochloride, the main metabolite of methamphetamine, is an indirectly acting sympathomimetic amine. Pholedrine hydrochloride is a cardiovascular agent exerting hypertensive and adrenergic effects. Pholedrine hydrochloride can produce mydriatic response and allow localization of the site of the interruption in the oculosympathetic pathway. Pholedrine hydrochloride can be used as a topical eye drop and a diagnostic agent for use in Horner's syndrome[1][2][3].
CAS Number
877-86-1
UNSPSC
12352005
Target
Drug Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/pholedrine-hydrochloride.html
Purity
99.63
Solubility
10 mM in DMSO
Smiles
OC1=CC=C(CC(C)NC)C=C1.Cl
Molecular Formula
C10H16ClNO
Molecular Weight
201.69
References & Citations
[1]Peinhardt GP. High-performance liquid chromatographic determination of pholedrine in human serum using ion-pair extraction and amperometric detection. J Chromatogr B Biomed Sci Appl. 1999 Apr 16;726 (1-2) :309-12.|[2]A T Bates, et al. Pholedrine: a substitute for hydroxyamphetamine as a diagnostic eyedrop test in Horner's syndrome. J Neurol Neurosurg Psychiatry. 1995 Feb;58 (2) :215-7.|[3]Richard Bade, et al. Pholedrine is a marker of direct disposal of methamphetamine. Sci Total Environ. 2021 Aug 15;782:146839.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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