Pholedrine

• Description:

  Pholedrine, the main metabolite of methamphetamine, is an indirectly acting sympathomimetic amine. Pholedrine is a cardiovascular agent exerting hypertensive and adrenergic effects. Pholedrine can produce mydriatic response and allow localization of the site of the interruption in the oculosympathetic pathway. Pholedrine can be used as a topical eye drop and a diagnostic agent for use in Horner's syndrome[1][2][3].

• UNSPSC:

  12352005

• Hazard Statement:

  H302-H315-H319-H335

• Target:

  Adrenergic Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Field of Research:

  Neurological Disease; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/pholedrine.html

• Solubility:

  10 mM in DMSO

• Smiles:

  OC1=CC=C(C=C1)CC(C)NC

• Molecular Formula:

  C10H15NO

• Molecular Weight:

  165.23

• Precautions:

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

• References & Citations:

  [1]A T Bates, et al. Pholedrine: a substitute for hydroxyamphetamine as a diagnostic eyedrop test in Horner's syndrome. J Neurol Neurosurg Psychiatry. 1995 Feb;58 (2) :215-7.|[2]Richard Bade, et al. Pholedrine is a marker of direct disposal of methamphetamine. Sci Total Environ. 2021 Aug 15;782:146839.|[3]Peinhardt GP. High-performance liquid chromatographic determination of pholedrine in human serum using ion-pair extraction and amperometric detection. J Chromatogr B Biomed Sci Appl. 1999 Apr 16;726 (1-2) :309-12.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [370-14-9]