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Methyl p-coumarate

CAT: 0804-HY-N1434-01Size: 5 gDry Ice: NoHazardous: No
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CAT#:0804-HY-N1434-01Size:5 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Methyl p-coumarate (Methyl 4-hydroxycinnamate), an orally active esterified derivative of p-Coumaric acid (pCA), can be isolated from the flower of Trixis michuacana var longifolia. Methyl p-coumarate could inhibit the melanin formation in B16 mouse melanoma cells. Methyl p-coumarate also has strong in vitro inhibitory effect on A. alternata and other pathogens[1][2].
CAS Number
3943-97-3
Product Name Alternative
Methyl 4-hydroxycinnamate
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Fungal
Type
Natural Products
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/methyl-p-coumarate.html
Purity
99.80
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(OC)/C=C/C1=CC=C(O)C=C1
Molecular Formula
C10H10O3
Molecular Weight
178.19
Precautions
H302, H315, H319, H335
References & Citations
[1]Kubo I, et, al. Methyl p-coumarate, a melanin formation inhibitor in B16 mouse melanoma cells. Bioorg Med Chem. 2004 Oct 15;12 (20) :5349-54.|[2]Yuan S, et, al. Defense Responses, Induced by p-Coumaric Acid and Methyl p-Coumarate, of Jujube (Ziziphus jujuba Mill.) Fruit against Black Spot Rot Caused by Alternaria alternate. J Agric Food Chem. 2019 Mar 13;67 (10) :2801-2810.|[3]Park JW, et al. Methyl P-Coumarate Ameliorates the Inflammatory Response in Activated-Airway Epithelial Cells and Mice with Allergic Asthma. Int J Mol Sci. 2022 Nov 28;23 (23) :14909.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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