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Leukotriene B4-d5

CAT: 0804-HY-107608S1Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-107608S1Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Leukotriene B4-d5 (LTB4-d5) is deuterium labeled Leukotriene B4. Leukotriene B4 (LTB4) is known as one of the most potent chemoattractants and activators of leukocytes and is involved in inflammatory diseases. Leukotriene B4 is also an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2][3][4].
Product Name Alternative
LTB4-d5
UNSPSC
12352211
Target
Endogenous Metabolite; Isotope-Labeled Compounds; Leukotriene Receptor; PROTAC Linkers
Type
Isotope-Labeled Compounds
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease; Others; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer; Inflammation/Immunology
Smiles
O[C@@H](/C=C/C=C/C=C\[C@H](CCCC(O)=O)O)C/C=C\CCCC([2H])(C([2H])([2H])[2H])[2H]
Molecular Formula
C20H27D5O4
Molecular Weight
341.50
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562|[3]S.WCrooks, et al. Leukotriene B4. The International Journal of Biochemistry & Cell Biology Volume 30, Issue 2, 27 March 1998, Pages 173-178.|[4]Takehiko Yokomizo, et al. Leukotriene B4: Metabolism and Signal Transduction. Archives of Biochemistry and Biophysics Volume 385, Issue 2, 15 January 2001, Pages 231-241.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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