DAS-5-oCRBN

• Description :

  DAS-5-oCRBN is a selective and potent PROTAC degrader of c-Src kinase. DAS-5-oCRBN has antiproliferative activity in both c-Src-dependent cell lines[1].

• UNSPSC :

  12352005

• Target :

  PROTACs; Src

• Type :

  Reference compound

• Related Pathways :

  PROTAC; Protein Tyrosine Kinase/RTK

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/das-5-ocrbn.html

• Purity :

  98.75

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  CC1=C(NC(C2=CN=C(NC3=CC(N4CCN(CC(N5CCN(C6=C7C(N(C8CCC(NC8=O)=O)C(C7=CC=C6)=O)=O)CC5)=O)CC4)=NC(C)=N3)S2)=O)C(Cl)=CC=C1

• Molecular Formula :

  C39H40ClN11O6S

• Molecular Weight :

  826.32

• References & Citations :

  [1]Mao W, et al. Selective and Potent PROTAC Degraders of c-Src Kinase. ACS Chem Biol. 2024 Jan 19;19 (1) :110-116.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported