Lys05

• Description:

  Lys05 (Lys01 trihydrochloride) is a novel lysosomal autophagy inhibitor with IC50 values of 3.6, 3.8, 6 and 7.9 μM for 1205Lu, c8161, LN229 and HT-29 cell line in the MTT assay.

• Product Name Alternative:

  Lys01 (trihydrochloride)

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Autophagy

• Type:

  Reference compound

• Related Pathways:

  Autophagy

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Lys01__trihydrochloride_.html

• Purity:

  99.74

• Solubility:

  DMSO : 5.41 mg/mL (ultrasonic) |H2O : 5.83 mg/mL (ultrasonic)

• Smiles:

  CN(CCNC1=CC=NC2=C1C=CC(Cl)=C2)CCNC3=CC=NC4=CC(Cl)=CC=C43.[H]Cl.[H]Cl.[H]Cl

• Molecular Formula:

  C23H26Cl5N5

• Molecular Weight:

  549.75

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]McAfee Q, et al. Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency. Proc Natl Acad Sci U S A. 2012 May 22;109 (21) :8253-8.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1391426-24-6]