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Dihydroberberine

CAT: 0804-HY-N1934-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N1934-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Dihydroberberine is a naturally occurring isoquinoline alkaloid with anti-inflammatory, anti-atherosclerotic, hypolipidemic and anti-tumor activities. Dihydroberberine inhibits the human ether-related gene (hERG) channel and significantly reduces the expression of heat shock protein 90 (Hsp90) and its interaction with hERG. Dihydroberberine also blocks the TLR4/MyD88/NF-κB signaling pathway to reduce pro-inflammatory cytokines and immunoglobulins, and has inhibitory effects on DSS -induced experimental colitis. Dihydroberberine also increases the sensitivity of lung cancer to sunitinib (HY-10255A), with synergistic efficacy[1][2].
CAS Number
483-15-8
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
HSP; Potassium Channel
Type
Natural Products
Related Pathways
Cell Cycle/DNA Damage; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease
Applications
COVID-19-anti-virus
Field of Research
Cancer; Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/dihydroberberine.html
Purity
99.30
Solubility
DMSO : 20 mg/mL (ultrasonic; warming; heat to 70°C)
Smiles
COC1=CC=C(C=C23)C(CN2CCC(C3=C4)=CC5=C4OCO5)=C1OC
Molecular Formula
C20H19NO4
Molecular Weight
337.37
Precautions
H302, H315, H319, H335
References & Citations
[1]Yu D, et al. Inhibitory effects and mechanism of dihydroberberine on hERG channels expressed in HEK293 cells. PLoS One. 2017 Aug 1;12 (8) :e0181823.|[2]Li C, et al. Dihydroberberine, an isoquinoline alkaloid, exhibits protective effect against dextran sulfate sodium-induced ulcerative colitis in mice. Phytomedicine. 2021 Sep;90:153631.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
HSP90

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