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Flubendazole (Standard)

CAT: 0804-HY-B0294R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0294R-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Flubendazole (Standard) is the analytical standard of Flubendazole. This product is intended for research and analytical applications. Flubendazole is an anthelmintic drug based on altering microtubule structure, inhibition of tubulin polymerization and disruption of microtubule function. Flubendazole induces apoptosis in human colorectal cancer (CRC) by blocking the STAT3 signaling axis and activation of autophagy. Flubendazole induces P53 expression and reduced Cyclin B1 and p-cdc2 expression. Flubendazole is an antitumor agent. Flubendazole can be used for worm and intestinal parasites[1][2].
CAS Number
31430-15-6
UNSPSC
12352005
Hazard Statement
H315-H319-H335
Target
Apoptosis; Autophagy; MDM-2/p53; Microtubule/Tubulin; Parasite; Reference Standards; STAT
Type
Reference Standards
Related Pathways
Anti-infection; Apoptosis; Autophagy; Cell Cycle/DNA Damage; Cytoskeleton; JAK/STAT Signaling; Others; Stem Cell/Wnt
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/flubendazole-standard.html
Smiles
O=C(OC)NC1=NC2=CC=C(C(C3=CC=C(F)C=C3)=O)C=C2N1
Molecular Formula
C16H12FN3O3
Molecular Weight
313.28
Precautions
P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501
References & Citations
[1]Zhou X, et al. Flubendazole inhibits glioma proliferation by G2/M cell cycle arrest and pro-apoptosis. Cell Death Discov. 2018 Feb 14;4:18.|[2]Shichong Lin, et al. Flubendazole demonstrates valid antitumor effects by inhibiting STAT3 and activating autophagy. J Exp Clin Cancer Res. 2019 Jul 8;38 (1) :293.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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