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Flubendazole-d3

CAT: 0804-HY-B0294S-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0294S-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Flubendazole-d3 is the deuterium labeled Flubendazole. Flubendazole is a safe and efficacious anthelmintic agent, which is widely used for anthelmintic to human, rodents and ruminants. Flubendazole exerts anticancer activities by mechanisms including inhibition of microtubule function. Flubendazole induces p53-mediated apoptosis and arrests G2/M cell cycle[1][2].
CAS Number
1173021-08-3
UNSPSC
12352005
Target
Apoptosis; Microtubule/Tubulin; Parasite
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton
Field of Research
Cancer; Infection
Purity
96.00
Solubility
10 mM in DMSO|DMSO : 4.17mg/mL (ultrasonic)
Smiles
O=C(C1=CC=C(F)C=C1)C2=CC=C(N=C(NC(OC([2H])([2H])[2H])=O)N3)C3=C2
Molecular Formula
C16H9D3FN3O3
Molecular Weight
316.30
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Michaelis M, et al. Identification of flubendazole as potential anti-neuroblastoma compound in a large cell line screen. Sci Rep. 2015 Feb 3;5:8202.|[3]Zhou X, et al. Flubendazole inhibits glioma proliferation by G2/M cell cycle arrest and pro-apoptosis. Cell Death Discov. 2018 Feb 14;4:18.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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450118-01Flubendazole-d3
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