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Entacapone

CAT: 0400-SIH-578-50MGSize: 50 mgDry Ice: NoHazardous: No
CAT#:0400-SIH-578-50MGSize:50 mg
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AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Entacapone is a selective and reversible inhibitor of the enzyme catechol-O-methyltransferase (COMT). It is used in the therapy of Parkinson's Disease as adjunctive therapy in conjuction with levodopa and carbidopa. It inhibits alpha synuclein and beta-amyloid oligomerization and fibrillogenesis.
Description
COMT inhibitor
CAS Number
130929-57-6
Product Name Alternative
(2E) -2-Cyano-3- (3,4-dihydroxy-5-nitrophenyl) -N, N-diethyl-2-propenamide
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Neuroscience | Neurodegeneration | Parkinson's Disease | Synuclein | Cell Signaling | Neurotransmission
Purity
>98% (HPLC) ; NMR (Conforms)
Weight
0.005
Format
Yellow powder
Solubility
May be dissolved in DMSO (30 mg/ml); or ethanol (3 mg/ml)
Molecular Formula
C14H15N3O5
Molecular Weight
305.3
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Di Giovanni S., et al. (2010) J Biol Chem. 285 (20): 14941-14954.

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