Entacapone

• Background:

  Entacapone is a selective and reversible inhibitor of the enzyme catechol-O-methyltransferase (COMT). It is used in the therapy of Parkinson's Disease as adjunctive therapy in conjuction with levodopa and carbidopa. It inhibits alpha synuclein and beta-amyloid oligomerization and fibrillogenesis.

• Description:

  COMT inhibitor

• Product Name Alternative:

  (2E) -2-Cyano-3- (3,4-dihydroxy-5-nitrophenyl) -N, N-diethyl-2-propenamide

• UNSPSC:

  41116105

• Type:

  Inhibitor

• Source:

  Synthetic

• Field of Research:

  Neuroscience | Neurodegeneration | Parkinson's Disease | Synuclein | Cell Signaling | Neurotransmission

• Purity:

  >98% (HPLC) ; NMR (Conforms)

• Weight:

  0.005

• Format:

  Yellow powder

• Solubility:

  May be dissolved in DMSO (30 mg/ml); or ethanol (3 mg/ml)

• Molecular Formula:

  C14H15N3O5

• Molecular Weight:

  305.3

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Di Giovanni S., et al. (2010) J Biol Chem. 285 (20): 14941-14954.

• CAS Number:

  130929-57-6