Midostaurin

• Background :

  Midostaurin is a broad spectrum protein kinase inhibitor. It also shows inhibition of PKCα, PKCβ and PKCγ isoforms, Flk, and c-kit. Midostaurin displays antiproliferative characteristics and the ability to induce apoptosis.

• Description :

  Kinase inhibitor

• Product Name Alternative :

  4'-N-Benzoyl-staurosporine, Midostaurin, CGP 41251

• UNSPSC :

  41116105

• Type :

  Inhibitor

• Source :

  Synthetic

• Field of Research :

  Cell Signaling | Cancer | Apoptosis | Cancer Growth Inhibitors | Tyrosine Kinase Inhibitors

• Purity :

  ≥98% (TLC)

• Weight :

  0.005

• Format :

  White to off-white powder

• Solubility :

  Soluble in DMSO (15 mg/ml), MDC (10 mg/ml), methanol (5 mg/ml) or 100% ethanol (2.5 mg/ml)

• Molecular Formula :

  C35H30N4O4

• Molecular Weight :

  570.6

• Precautions :

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations :

  1. Fabbro D., et al. (2000) Anti-Cancer Drug Design. 15(1): 17–28. 2. Odgerel, T., et al. (2008) Oncogene. 27(22): 3102–3110. 3. Bahlis, N.J., et al. (2005) Leukemia & Lymphoma. 46(6): 899–908.

• CAS Number :

  120685-11-2