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Lapatinib

CAT: 0400-SIH-459-50MGSize: 50 mgDry Ice: NoHazardous: No
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CAT#:0400-SIH-459-50MGSize:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Lapatinib is a tyrosine kinase inhibitor. Specifically, it interrupts the ErbB/neu and epidermal growth factor receptor (EGFR) pathways. It is an antineoplastic agent used in breast cancer research. In solid tumor cells, Lapatinib binds to the ATP-binding pocket of the protein kinase domains on EGFR/ErbB, preventing self-phosphorylation.
Description
Dual EGFR/HER2 Tyrosine Kinase Inhibitor
CAS Number
231277-92-2
Product Name Alternative
N-[3-chloro-4-[ (3-fluorophenyl) methoxy]phenyl]-6-[5-[ (2-methylsulfonylethylamino) methyl]furan-2-yl]quinazolin-4-amine
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cell Signaling | Cancer | Apoptosis | Cancer Growth Inhibitors | Growth Factor Receptor Inhibitors
Purity
≥99%
Weight
0.05
Format
Yellow crystalline solid
Solubility
Solubility in water is 0.007 mg/ml and in 0.1N HCl is 0.001 mg/ml at 25° C
Molecular Formula
C29H26ClFN4O4S
Molecular Weight
581.1
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Chien A.J., et al. (2014) J. Clin. Oncol: J. Am. Clin. Oncol. 32(14): 1472–1479. 2. Dahal B.K., et al. (2010) Am. J. Resp. Critical Care Med. 181(2): 158–167.

Alternative Products

CatalogName
A8218-100Lapatinib

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