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Hydroxychloroquine

CAT: 0400-SIH-400-10MGSize: 10 mgDry Ice: NoHazardous: No
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CAT#:0400-SIH-400-10MGSize:10 mg
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Background
Hydroxychloroquine was first established as an anti-malarial agent, but is now being used in a variety of applications, including the inhibition of autopagy. Hydroxychloroquine is a lysosomotropic agent and therefore inhibits autophagy by obstructing the final step of autophagy, the fusion of autophagosomes with lysosomes, thereby preventing the acidification of the lysosomal compartment. In the context of cancer, autophagy is thought to be adopted by tumor cells to survive in the nutrient-deficient and hypoxic tumor environment. Hydroxychloroquine has therefore been studied extensively within the context of certain cancers.
Description
Autophagy inhibitor
CAS Number
747-36-4
Product Name Alternative
Hydroxychloroquine sulphate, 7-Chloro-4-[4- (N-ethyl-N-b-hydroxyethylamino) -1-methylbutylamino]quinoline
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cancer | Autophagy
Purity
≥98%
Weight
0.01
Format
White to off-white powder.
Solubility
Soluble in greater than 20 mg/ml H2O.
Molecular Formula
C18H26ClN3O•H2SO4
Molecular Weight
433.95
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. van Loosdregt J., et al. (2013) J Allergy Clin Immunol. 131(5): 1443-6.e1. 2. Lotze M.T., et al. (2013) Cancer J. 19(4): 341-7. 3. Xie X., et al. (2013) PLoS One. 8(1): e55096.

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