DAPT

• Background:

  Inhibitor of γ-secretase; causes a reduction in Aβ40 and Aβ42 levels in human primary neuronal cultures (IC50 values are 115 and 200 nM for total Aβ and Aβ42 respectively) and in brain extract, cerebrospinal fluid and plasma in vivo. Does not affect APPα and APPβ levels. Blocks Notch signaling in hybrid human-mouse fetal thymus organ culture (FTOC). Activity causes neural cells to commit to neuronal differentiation.

• Description:

  γ-secretase inhibitor

• Product Name Alternative:

  N-[ (3,5-Difluorophenyl) acetyl]-L-al­anyl-2-phenyl]glycine-1,1-dimethylethyl ester

• UNSPSC:

  41116105

• Type:

  Inhibitor

• Source:

  Synthetic

• Field of Research:

  Neuroscience | Cell Signaling | Neuroscience | Neurodegeneration | Amyloid

• Purity:

  >99%

• Weight:

  0.005

• Format:

  White to off-white powder

• Solubility:

  Soluble to 100 mM in DMSO

• Molecular Formula:

  C23H26F2N2O4

• Molecular Weight:

  432.46

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Dovey H.F., et al. (2001) J. Neurochem. 76(1): 173-81. 2. De Smedt M., et al. (2005) Blood. 106(10): 3498-506. 3. Kanungo J., et al. (2008) J. Neurochem. 106(5): 2236-48.

• CAS Number:

  208255-80-5