Nocodazole

• Background:

  Nocodazole also known as Oncodazole. It is an antimitotic agent, associated with the activity of depolymerization of the microtubules (1). Nocadozole has high affinity with Tubulin but little is known on the mechanism of binding. Studies have shown that Nocadozole binds differently to the various α/β isotypes of Tubulin. By measuring the dissociation constants, with the given binding sites, a novel approach of therapeutic agents is under study (2).

• Description:

  Microtubule inhibitor

• Product Name Alternative:

  Methyl (5-[2-thienylcarbonyl]-1H-benzimidazol-2-yl

• UNSPSC:

  41116105

• Type:

  Inhibitor

• Source:

  Synthetic

• Field of Research:

  Cancer | Apoptosis | Neuroscience

• Purity:

  ≥98% (HPLC) ; NMR (Conforms)

• Weight:

  0.05

• Format:

  White to off-white powder.

• Solubility:

  May be dissolved in DMSO (10 mg/ml, warm)

• Molecular Formula:

  C14H11N3O3S

• Molecular Weight:

  301.3

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Vasquez RJ., Howell B., Yvon AM., Wadsworth P., Cassimus L. (1997) Mol Biol Cell. 8(6): 973-985. 2. Kelian Xu., Schwarz P,. Luduena R,. (2002) Drug Drug Dev.Re. 55: 91-96.

• CAS Number:

  31430-18-9