Nocodazole

• UNSPSC Description:

  Nocodazole (Oncodazole) is a rapidly-reversible inhibitor of microtubule. Nocodazole binds to β-tubulin and disrupts microtubule assembly/disassembly dynamics, which prevents mitosis and induces apoptosis in tumor cells. Nocodazole inhibits Bcr-Abl, and activates CRISPR/Cas9.

• Target Antigen:

  Apoptosis; Autophagy; Bcr-Abl; CRISPR/Cas9; Microtubule/Tubulin

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Autophagy;Cell Cycle/DNA Damage;Cytoskeleton;Protein Tyrosine Kinase/RTK

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Nocodazole.html

• Smiles:

  O=C(OC)NC1=NC2=CC=C(C(C3=CC=CS3)=O)C=C2N1

• Molecular Weight:

  301.32

• References & Citations:

  [1]Park H, et al. Nocodazole is a high-affinity ligand for the cancer-related kinases ABL, c-KIT, BRAF, and MEK. ChemMedChem. 2012 Jan 2;7(1):53-6.|[2]Keliang Xu, et al. Interaction of nocodazole with tubulin isotypes. Drug Development Research 2002|[3]Wang YJ, et al. R-41400 potentiates the antitumor effects of nocodazole: In vivo therapy for human tumor xenografts in nude mice. Mol Carcinog. 2002 Aug;34(4):199-210.|[4]Signoretto E, et al. Nocodazole Induced Suicidal Death of Human Erythrocytes. Cell Physiol Biochem. 2016;38(1):379-92.|[5]Zhang JP, et al. Efficient precise knockin with a double cut HDR donor after CRISPR/Cas9-mediated double-stranded DNA cleavage. Genome Biol. 2017 Feb 20;18(1):35.|[6]Anutosh Ganguly, et al. The role of microtubules and their dynamics in cell migration. J Biol Chem. 2012 Dec 21;287(52):43359-69.

• Shipping Conditions:

  Room Temperature

• CAS Number:

  31430-18-9