Nocodazole

CAT: 0804-HY-13520-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-13520-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Nocodazole (Oncodazole) is a rapidly-reversible inhibitor of microtubule. Nocodazole binds to β-tubulin and disrupts microtubule assembly/disassembly dynamics, which prevents mitosis and induces apoptosis in tumor cells. Nocodazole inhibits Bcr-Abl.
CAS Number
[31430-18-9]
Product Name Alternative
Oncodazole; R17934
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Autophagy; Bcr-Abl; CRISPR/Cas9; Microtubule/Tubulin; Mitosis
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; Cell Cycle/DNA Damage; Cytoskeleton; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Nocodazole.html
Purity
99.59
Solubility
DMSO : 16.67 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(OC)NC1=NC2=CC=C(C(C3=CC=CS3)=O)C=C2N1
Molecular Formula
C14H11N3O3S
Molecular Weight
301.32
Precautions
H302, H315, H319, H335
References & Citations
[1]Park H, et al. Nocodazole is a high-affinity ligand for the cancer-related kinases ABL, c-KIT, BRAF, and MEK. ChemMedChem. 2012 Jan 2;7 (1) :53-6.|[2]Keliang Xu, et al. Interaction of nocodazole with tubulin isotypes. Drug Development Research 2002|[3]Wang YJ, et al. R-41400 potentiates the antitumor effects of nocodazole: In vivo therapy for human tumor xenografts in nude mice. Mol Carcinog. 2002 Aug;34 (4) :199-210.|[4]Signoretto E, et al. Nocodazole Induced Suicidal Death of Human Erythrocytes. Cell Physiol Biochem. 2016;38 (1) :379-92.|[5]Zhang JP, et al. Efficient precise knockin with a double cut HDR donor after CRISPR/Cas9-mediated double-stranded DNA cleavage. Genome Biol. 2017 Feb 20;18 (1) :35.|[6]Anutosh Ganguly, et al. The role of microtubules and their dynamics in cell migration. J Biol Chem. 2012 Dec 21;287 (52) :43359-69.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Abl

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