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Temozolomide

CAT: 0400-SIH-363-100MGSize: 100 mgDry Ice: NoHazardous: No
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CAT#:0400-SIH-363-100MGSize:100 mg
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Background
Temozolomide is a membrane permeable DNA alkylating agent which acts as an anti-tumor and anti-angiogenic agent by alkylating the N-7 or O-6 positions of guanine residues which triggers tumor cell death (1-2). It has been used clinically as an anti-cancer agent (3) and has been found to induce autophagy in a variety of cell lines (4).
Description
AGT inhibitor
CAS Number
85622-93-1
Product Name Alternative
3-Methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide; 8-Carbamoyl-3-methylimidazo[5,1-d]-1,2,3,5-tetrazin-4 (3H) -one
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cancer | Apoptosis
Purity
≥99% (TLC) ; NMR (Conforms)
Weight
0.1
Format
Off white powder
Solubility
Soluble in DMSO (25 mg/ml, warm) or water (weakly)
Molecular Formula
C6H6N6O2
Molecular Weight
194.2
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Kurzen H., et al. (2003) Anticancer Drugs. 14: 515. 2. Gunther W., et al. (2003) Br. J. Cancer. 88: 463. 3. Danson S.J., et al. (2001) Expert Rev. Anticancer Ther. 10: 13. 4. Natsumeda M., et al. (2011) Neuropathology. 31: 486.

Alternative Products

CatalogName
B1399-5.1Temozolomide

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