Bml-278

• Background:

  A structurally novel activator of SIRT1 (EC150=1 µM). Displays selectivity over SIRT2 and 3 (EC150=25 and 50 µM respectively). Cell permeable.

• Description:

  SIRT1 activator

• Product Name Alternative:

  N-Benzyl-3,5-dicarbethoxy-4-phenyl-1,4-dihydropyridine

• UNSPSC:

  41116105

• Type:

  Inhibitor

• Source:

  Synthetic

• Field of Research:

  Cell Signaling | Epigenetics and Nuclear Signaling

• Purity:

  >98% (TLC), NMR conforms

• Weight:

  0.005

• Format:

  Off-White Solid

• Solubility:

  Soluble in 5 mg/ml DMSO

• Molecular Formula:

  C24H25NO4

• Molecular Weight:

  391.5

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Mai A., et al. (2009) J. Med. Chem. 52: 5496.