Bml-278

• Background :

  A structurally novel activator of SIRT1 (EC150=1 µM). Displays selectivity over SIRT2 and 3 (EC150=25 and 50 µM respectively). Cell permeable.

• Description :

  SIRT1 activator

• Product Name Alternative :

  N-Benzyl-3,5-dicarbethoxy-4-phenyl-1,4-dihydropyridine

• UNSPSC :

  41116105

• Type :

  Inhibitor

• Source :

  Synthetic

• Field of Research :

  Cell Signaling | Epigenetics and Nuclear Signaling

• Purity :

  >98% (TLC), NMR conforms

• Weight :

  0.025

• Format :

  Off-White Solid

• Solubility :

  Soluble in 5 mg/ml DMSO

• Molecular Formula :

  C24H25NO4

• Molecular Weight :

  391.5

• Precautions :

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations :

  1. Mai A., et al. (2009) J. Med. Chem. 52: 5496.