Nutlin-3

• Background :

  MDM2 antagonist; inhibits the MDM2-p53 interaction (IC50 = 0.09 µM) and activates p53. Antiproliferative agent; induces apoptosis in cancer cells.

• Description :

  P53/mdm2 inhibitor

• Product Name Alternative :

  (±) -4-[4,5-Bis (4-chlorophenyl) -2- (2-isopropoxy-4-methoxy-phenyl) -4,5- dihydro-imidazole -1-carbonyl]-piperazin-2-one

• UNSPSC :

  41116105

• Type :

  Inhibitor

• Source :

  Synthetic

• Field of Research :

  Cancer | Apoptosis | Cancer Growth Inhibitors | p53/mdm2 Inhibitors

• Purity :

  >98%

• Weight :

  0.005

• Format :

  Yellow solid

• Solubility :

  Soluble in 100 mM DMSO and Ethanol

• Molecular Formula :

  C30H30Cl2N4O4

• Molecular Weight :

  581.9

• Precautions :

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations :

  1. Vassilev et al (2004) Science 303: 844.

• CAS Number :

  548472-68-0