Nutlin-3

• Background:

  MDM2 antagonist; inhibits the MDM2-p53 interaction (IC50 = 0.09 µM) and activates p53. Antiproliferative agent; induces apoptosis in cancer cells.

• Description:

  p53/mdm2 inhibitor

• Product Name Alternative:

  (±)-4-[4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5- dihydro-imidazole -1-carbonyl]-piperazin-2-one

• UNSPSC:

  41116105

• Source:

  Synthetic

• Purity:

  >98%

• Weight:

  0.005

• Format:

  Yellow solid

• Solubility:

  Soluble in 100 mM DMSO and Ethanol

• Molecular Formula:

  C30H30Cl2N4O4

• Molecular Weight:

  581.9

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Vassilev et al (2004) Science 303: 844.

• CAS Number:

  548472-68-0