Cytochalasin D

• Background:

  Cytochalasins have the ability to bind to actin filaments and block polymerization and elongation of actin. As a result, they can change cellular morphology, inhibit cellular processes and cause cells to undergo apoptosis (1). Cytochalasin D in particular can inhibit protein synthesis (2).

• Description:

  Actin polymerization inhibitor

• Product Name Alternative:

  (3S,3aR,4S,6S,6aR,7E,10S,12S,13E,15R,15aR) -3-Benzyl-6-hydroxy-4,10,12-trimethyl-5-methylene-1-oxo-2,3,3a,4,5,6,6a,9,10,11,12,15-dodecahydro-1H-cycloundeca[d]isoindol-15-yl acetate, Zygosporin A

• UNSPSC:

  41116105

• Type:

  Inhibitor

• Source:

  Synthetic

• Field of Research:

  Cancer | Apoptosis

• Purity:

  >98% (TLC) ; NMR (Conforms)

• Weight:

  0.005

• Format:

  White Solid

• Solubility:

  Soluble to 10 mM in ethanol and to 50 mM in DMSO

• Molecular Formula:

  C30H37NO6

• Molecular Weight:

  507.63

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1.  Haidle A., and Myers A. (2004) Proc Natl Acad Sci. 101(33): 12048-12053. 2. Ornelles et al., (1986) Mol Cell Biol. 6(5): 1650-1662.

• CAS Number:

  22144-77-0