Actinomycin D

• Background:

  The actinomycins are a class of polypeptide antibiotics. Actinomycin D inhibits transcription by binding DNA at the transcription initiation complex and preventing elongation by RNA polymerase (1). Actinomycin D has been used as a chemotherapy drug (2), and an antibiotic.

• Description:

  Transcription inhibitor

• Product Name Alternative:

  2-Amino-N, N'-bis (6,13-diisopropyl-2,5,9-trimethyl-1,4,7,11,14-pentaoxohexadecahydro-1H-pyrrolo[2,1-i][1,4,7,10,13]oxatetraazacyclohexadecin-10-yl) -4,6-dimethyl-3-oxo-3H-phenoxazine-1,9-dicarboxamide

• UNSPSC:

  41116105

• Type:

  Inhibitor

• Source:

  Synthetic

• Field of Research:

  Cancer | Apoptosis

• Purity:

  >98%

• Weight:

  0.05

• Format:

  White Solid

• Solubility:

  Soluble to 50 mM in DMSO

• Molecular Formula:

  C62H86N12O16

• Molecular Weight:

  1255.43

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Sobell H. (1985) Proc Natl Acad Sci USA. 82(16): 5328-31. 2. Turan T., et al. (2006) Int J Gynecol Cancer. 16(3): 1432-1438.

• CAS Number:

  50-76-0