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N, N-Dimethylsphingosine

CAT: 0400-SIH-235-5MGSize: 5 mgDry Ice: NoHazardous: No
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CAT#:0400-SIH-235-5MGSize:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
N,N-dimethylsphingosine is a potent and specific inhibitor of sphingosine kinase. It is a natural metabolite of sphiongosine in some cancel cell lines and tissues (1). It also induces apoptosis, but it is not an inhibitor of protein kinase C (2).
Description
Kinase inhibitor
CAS Number
119567-63-4
Product Name Alternative
(2S,3R,4E) -2- (Dimethylamino) -4-octadecene-1,3-diol
UNSPSC
41116105
Type
Inducer
Source
Synthetic
Field of Research
Cancer | Apoptosis | Cancer Growth Inhibitors | Tyrosine Kinase Inhibitors
Purity
>98%
Weight
0.005
Format
White to off-white waxy solid, or viscous oil
Solubility
Soluble in DMSO (25 mg/ml) or 100% ethanol (25 mg/ml)
Molecular Formula
C20H41NO2
Molecular Weight
327.6
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Yatomi Y., et al. (1996) Biochem. 35: 626-633. 2. Sweeny E.A., et al. (1996) Int J Cancer. 66(3): 358-366.

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