HSP90 alpha Protein

CAT: 0400-SPR-101BSize: 100 µgDry Ice: NoHazardous: No
CAT#:0400-SPR-101BSize:100 µg
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Background
HSP90 alpha is a highly conserved molecular chaperone that plays a central role in maintaining protein homeostasis under both normal and stress conditions. In the context of neuroscience, HSP90 alpha is increasingly recognized for its involvement in the folding, stabilization, and functional regulation of key neuronal proteins, including kinases, transcription factors, and hormone receptors. In neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and Huntington’s, the accumulation of misfolded proteins and impaired proteostasis are hallmark features. HSP90 alpha contributes to the cellular defense against these pathologies by stabilizing client proteins and preventing their aggregation. However, its chaperone activity can also inadvertently preserve the function of pathogenic proteins, such as hyperphosphorylated tau or mutant huntingtin, thereby influencing disease progression. HSP90 alpha forms dynamic complexes with co-chaperones like Cdc37 and p23, modulating the fate of its client proteins. Pharmacological inhibition of HSP90 alpha has shown promise in preclinical models by promoting the degradation of neurotoxic proteins and restoring proteostasis.
Description
Human Recombinant HSP90 alpha Protein
Product Name Alternative
HSP90AA1, HSP90-alpha, HSP90A, HSPCA, HSPC1, Heat shock protein HSP 90-alpha, Heat shock 90 kDa protein 1 alpha isoform, HSPCAL3, HSP86, HSP89A, HSP90Alpha
UNSPSC
12352202
UN Code
Non-hazardous
Hazard Statement
Non-hazardous
Gene ID
3320
Swiss Prot
P07900
Accession Number
NP_001017963.2
Cellular Locus
Cytoplasm | Melanosome
Expression System
E. coli
Host
E. coli
Origin Species
Human
Target
HSP90 alpha
Conjugation
No tag
Nature
Recombinant
Applications
WB | SDS-PAGE | ATPase Activity Assay | Surface Plasmon Resonance (SPR) | DARTs Assay (Drug Affinity Responsive Target Stability Assay) | SB (Skin Blotting)
Field of Research
Cancer | Heat Shock | Cell Signaling | Protein Trafficking | Chaperone Proteins | Cancer | Tumor Biomarkers
Purification Method
Affinity Purified
Purification
Affinity Purified
Limit Of Detection
This product has been certified >90% pure using SDS­PAGE analysis.
Concentration
Lot/batch specific. See included datasheet.
Purity
>90%
Weight
0.1
Length
Full Length
Buffer
50mM Tris/HCl pH7.5, 5mM Bme, 0.3M NaCl, 10% glycerol
Molecular Weight
~90 kDa
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For research use only.
Shipping Conditions
Blue Ice or 4ºC
Storage Conditions
-20ºC
Protein Length
Full Length
Background Reference 01
1. Arlander S.J.H., et al. (2003) J Biol Chem. 278: 52572-52577. 2. Pearl H., et al. (2001) Adv Protein Chem. 59:157-186. 3. Neckers L., et al. (2002) Trends Mol Med. 8:S55-S61. 4. Pratt W., Toft D. (2003) Exp Biol Med. 228:111-133. 5. Pratt W., Toft D. (1997) Endocr Rev. 18: 306–360. 6. Pratt W.B. (1998) Proc Soc Exptl Biol Med. 217: 420–434. 7. Whitesell L., et al. (1994) Proc Natl Acad Sci USA. 91: 8324– 8328.
Location
Cytoplasm | Melanosome
Immunogen Species
Human
Product MSDS
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