HSP90 alpha Protein

• Background:

  HSP90 alpha is a highly conserved molecular chaperone that plays a central role in maintaining protein homeostasis under both normal and stress conditions. In the context of neuroscience, HSP90 alpha is increasingly recognized for its involvement in the folding, stabilization, and functional regulation of key neuronal proteins, including kinases, transcription factors, and hormone receptors. In neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and Huntington’s, the accumulation of misfolded proteins and impaired proteostasis are hallmark features. HSP90 alpha contributes to the cellular defense against these pathologies by stabilizing client proteins and preventing their aggregation. However, its chaperone activity can also inadvertently preserve the function of pathogenic proteins, such as hyperphosphorylated tau or mutant huntingtin, thereby influencing disease progression. HSP90 alpha forms dynamic complexes with co-chaperones like Cdc37 and p23, modulating the fate of its client proteins. Pharmacological inhibition of HSP90 alpha has shown promise in preclinical models by promoting the degradation of neurotoxic proteins and restoring proteostasis.

• Description:

  Human Recombinant HSP90 alpha Protein

• Product Name Alternative:

  HSP90AA1, HSP90-alpha, HSP90A, HSPCA, HSPC1, Heat shock protein HSP 90-alpha, Heat shock 90 kDa protein 1 alpha isoform, HSPCAL3, HSP86, HSP89A, HSP90Alpha

• UNSPSC:

  12352202

• UN Code:

  Non-hazardous

• Hazard Statement:

  Non-hazardous

• Gene ID:

  3320

• Swiss Prot:

  P07900

• Accession Number:

  NP_001017963.2

• Cellular Locus:

  Cytoplasm | Melanosome

• Expression System:

  E. coli

• Host:

  E. coli

• Origin Species:

  Human

• Target:

  HSP90 alpha

• Conjugation:

  No tag

• Nature:

  Recombinant

• Applications:

  WB | SDS-PAGE | ATPase Activity Assay | Surface Plasmon Resonance (SPR) | DARTs Assay (Drug Affinity Responsive Target Stability Assay) | SB (Skin Blotting)

• Field of Research:

  Cancer | Heat Shock | Cell Signaling | Protein Trafficking | Chaperone Proteins | Cancer | Tumor Biomarkers

• Purification Method:

  Affinity Purified

• Purification:

  Affinity Purified

• Limit Of Detection:

  This product has been certified >90% pure using SDS­PAGE analysis.

• Concentration:

  Lot/batch specific. See included datasheet.

• Purity:

  >90%

• Weight:

  0.05

• Length:

  Full Length

• Buffer:

  50mM Tris/HCl pH7.5, 5mM Bme, 0.3M NaCl, 10% glycerol

• Molecular Weight:

  ~90 kDa

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For research use only.

• Shipping Conditions:

  Blue Ice or 4ºC

• Storage Conditions:

  -20ºC

• Protein Length:

  Full Length

• Background Reference 01:

  1. Arlander S.J.H., et al. (2003) J Biol Chem. 278: 52572-52577. 2. Pearl H., et al. (2001) Adv Protein Chem. 59:157-186. 3. Neckers L., et al. (2002) Trends Mol Med. 8:S55-S61. 4. Pratt W., Toft D. (2003) Exp Biol Med. 228:111-133. 5. Pratt W., Toft D. (1997) Endocr Rev. 18: 306–360. 6. Pratt W.B. (1998) Proc Soc Exptl Biol Med. 217: 420–434. 7. Whitesell L., et al. (1994) Proc Natl Acad Sci USA. 91: 8324– 8328.

• Location:

  Cytoplasm | Melanosome

• Immunogen Species:

  Human