PV-1019

CAT: 0804-HY-125203-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-125203-01Size:5 mg
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Description
PV-1019 (NSC 744039) is a potent, selective Chk2 inhibitor with an IC50 value of 24 nM. PV-1019 inhibits the Topotecan (HY-13768) -induced Chk2 autophosphorylation. PV-1019 inhibits IR-induced apoptosis[1].
CAS Number
[1093793-05-5]
Product Name Alternative
NSC 744039
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Checkpoint Kinase (Chk)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pv-1019.html
Purity
99.30
Solubility
DMSO : 40 mg/mL (ultrasonic; adjust pH to 3 with 1 M HCl)
Smiles
O=C(C(N1)=CC2=C1C([N+]([O-])=O)=CC=C2)NC3=CC=C(/C(C)=N/NC(N)=N)C=C3
Molecular Formula
C18H17N7O3
Molecular Weight
379.37
Precautions
H302, H315, H319, H335
References & Citations
[1]Jobson AG, et, al. Cellular inhibition of checkpoint kinase 2 (Chk2) and potentiation of camptothecins and radiation by the novel Chk2 inhibitor PV1019 [7-nitro-1H-indole-2-carboxylic acid {4-[1- (guanidinohydrazone) -ethyl]-phenyl}-amide]. J Pharmacol Exp Ther. 2009 Dec;331 (3) :816-26.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Chk2

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