PV-1019

• Description :

  PV-1019 (NSC 744039) is a potent, selective Chk2 inhibitor with an IC50 value of 24 nM. PV-1019 inhibits the Topotecan (HY-13768) -induced Chk2 autophosphorylation. PV-1019 inhibits IR-induced apoptosis[1].

• CAS Number :

  [1093793-05-5]

• Product Name Alternative :

  NSC 744039

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Checkpoint Kinase (Chk)

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/pv-1019.html

• Purity :

  99.30

• Solubility :

  DMSO : 40 mg/mL (ultrasonic; adjust pH to 3 with 1 M HCl)

• Smiles :

  O=C(C(N1)=CC2=C1C([N+]([O-])=O)=CC=C2)NC3=CC=C(/C(C)=N/NC(N)=N)C=C3

• Molecular Formula :

  C18H17N7O3

• Molecular Weight :

  379.37

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Jobson AG, et, al. Cellular inhibition of checkpoint kinase 2 (Chk2) and potentiation of camptothecins and radiation by the novel Chk2 inhibitor PV1019 [7-nitro-1H-indole-2-carboxylic acid {4-[1- (guanidinohydrazone) -ethyl]-phenyl}-amide]. J Pharmacol Exp Ther. 2009 Dec;331 (3) :816-26.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Chk2