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JNJ-1013

CAT: 0804-HY-153188-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-153188-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
JNJ-1013 is a potent and selective IRAK1 PROTAC degrader with an IC50s of 72, 443, 1071 nM for IRAK1, IRAK4, VHL FP respectively. JNJ-1013 induces apoptosis and increases the expression of cleavaged PARP. JNJ-1013 decreases the expression IRAK1, p-IKBα, pSTAT3 (Tyr705) (Pink: ligand for target protein ; black: linker (HY-Y1760) ; Blue: E3 ligase ligand (HY-112078) ).
CAS Number
2597343-08-1
UNSPSC
12352005
Target
Apoptosis; IRAK; PROTACs
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/jnj-1013.html
Purity
99.80
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
COC(C=C1N(CC2)CCC2OCC(N[C@@H](C(C)(C)C)C(N3[C@@H](C[C@H](C3)O)C(N[C@H](C4=CC=C(C5=C(C)N=CS5)C=C4)C)=O)=O)=O)=C(C=C1)NC(C6=CC=CC(C7=CC=NN7)=N6)=O
Molecular Formula
C46H55N9O7S
Molecular Weight
878.05
References & Citations
[1]Fu L, et al. Discovery of Highly Potent and Selective IRAK1 Degraders to Probe Scaffolding Functions of IRAK1 in ABC DLBCL. J Med Chem. 2021 Aug 12;64 (15) :10878-10889.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IRAK1; IRAK4

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