Products for Research Use Only
RegisterLogin

Methotrexate-d3 (diammonium)

CAT: 0804-HY-14519S1-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-14519S1-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Methotrexate-d3 diammonium is the deuterium labeled Methotrexate diammonium. Methotrexate (Amethopterin), an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia) [1][2][3].
UNSPSC
12352005
Target
Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Others
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Metabolic Disease; Inflammation/Immunology
Purity
99.69
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
NC1=NC(N)=NC2=C1N=C(CN(C3=CC=C(C(N[C@H](C(O)=O)CCC(O)=O)=O)C=C3)C([2H])([2H])[2H])C=N2.N.N
Molecular Formula
C20H25D3N10O5
Molecular Weight
491.52
References & Citations
[1]Tian H, et al. Understanding the mechanisms of action of methotrexate: implications for the treatment of rheumatoid arthritis. Bull NYU Hosp Jt Dis. 2007;65 (3) :168-73.|[2]Swierkot J, et al. Methotrexate in rheumatoid arthritis. Pharmacol Rep. 2006 Jul-Aug;58 (4) :473-92.|[3]Ehab Tousson, et al. The Effect of L-carnitine on Amethopterin-induced Toxicity in Rat Large Intestine. Journal of Cancer Research and Treatment, 2014 2 (3), pp 55-63.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

Related Products

CatalogName
HY-14519SMethotrexate-d3
HY-14519CS-01(R) -Methotrexate-d3
HY-108251SMethotrexate metabolite-d3
HY-W743645Methotrexate-d3 Heptaglutamate Trifluoroacetate
HY-W745177Methotrexate-d3 Pentaglutamate Trifluoroacetate
HY-W745173Methotrexate-d3 Triglutamate Trifluoroacetate
HY-W743130DL-Methotrexate-d3 Dipotassium Salt
HY-W769792Methotrexate-d3 Diglutamate TFA Sulfate
HY-W6542277-Hydroxy methotrexate-d3 (ammonium salt)
HY-121151(±) -Methotrexate

Alternative Products

CatalogName
430188-014-Amino-2-methyl-5-pyrimidinemethanol Dihydrogen Phosphate Diammonium Salt-d3
CS-O-06766Methotrexate-d3
TRC-M260667-0.5MG(R)-Methotrexate-d3
464000-01(R) -Methotrexate-d3
163935DL-Methotrexate-d3
sc-218707Methotrexate-methyl-d3
164885Methotrexate-d3 Heptaglutamate
454507-01Methotrexate-d3 Tetraglutamate Trifluoroacetate
454506Methotrexate-d3 Pentaglutamate Trifluoroacetate
454504-01Methotrexate-d3 Diglutamate Trifluoroacetate

Popular Products