Methotrexate metabolite-d3

Methotrexate metabolite-d3

• CAS Number: 1794780-00-9
• UNSPSC Description: Methotrexate metabolite-d3 is the deuterium labeled Methotrexate metabolite. Methotrexate metabolite (DAMPA), the active metabolite of Methotrexate. Methotrexate is a folic acid antagonist that is widely used as an immunosuppressant and chemotherapeutic agent[1].
• Target Antigen: Antifolate; Drug Metabolite; Isotope-Labeled Compounds
• Type: Isotope-Labeled Compounds
• Related Pathways: Cell Cycle/DNA Damage;Metabolic Enzyme/Protease;Others
• Field of Research: Inflammation/Immunology
• Solubility: 10 mM in DMSO
• Smiles: NC1=NC(N)=NC2=C1N=C(CN(C3=CC=C(C=C3)C(O)=O)C([2H])([2H])[2H])C=N2
• Molecular Weight: 328.34
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Schofield RC, et al. Development and validation of a turbulent flow chromatography and tandem mass spectrometry method for the quantitation of methotrexate and its metabolites 7-hydroxy methotrexate and DAMPA in serum. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Oct 1;1002:169-75.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported